5-CHLOROSALICYLIC ACID

PRODUCT IDENTIFICATION
CAS NO. 321-14-2

5-CHLOROSALICYLIC ACID
EINECS NO. 206-283-9
FORMULA HOC6H3ClCOOH
MOL WT. 172.57
H.S. CODE 2918.21
TOXICITY Oral rat LD50: 250 mg/kg
SYNONYMS 5-Chloro-2-hydroxybenzoic acid; 5-Chlorosalicylic acid;
2-Hydroxy-5-chlorobenzoic acid; 5-CSA; 5-Chlorsalicylsäure (German); ácido 5-Clorosalicílico (Spanish); Acide 5-chlorosalicylique (French);
SMILES  

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE white crystalline powder
MELTING POINT 171 - 173 C
BOILING POINT  
SPECIFIC GRAVITY 1.44
SOLUBILITY IN WATER Slight soluble (soluble in alcohol, ether, chloroform)
AUTOIGNITION

 
pH

 
VAPOR DENSITY  
NFPA RATINGS Health: 2 Flammability: 1 Reactivity: 0
REFRACTIVE INDEX

 
FLASH POINT  
STABILITY Stable under ordinary conditions.

GENERAL DESCRIPTION & APPLICATIONS
Salicylic Acid is a white crystalline powder or needle-shaped crystals with sweetish taste; soluble in acetone, ether, alcohol, boiling water, benzene and turpentine, sparingly soluble in chloroformbenzene, slightly soluble in water; melts at 158°C. The sodium salt form (sodium salicylate) is common commercially, prepared from mainly sodium phenolate with carbon dioxide under heating and pressure. It contains both a hydroxyl and a carboxyl group, which react with either an acid or an alcohol. The carboxyl group forms esters with alcohols; e.g. methyl salicylate is formed with methanol, which used in food flavorings and preservatives; menthyl salicylate is formed with methanol, which is used in suntan lotions. The hydroxyl group reacts with acetic acid to form acetylsalicylic acid (called aspirin) which is the most widely common antiseptic and antipyretic agent. Phenyl salicylate (called salol) is formed with phenol, which is also used as an antiseptic and antipyretic agent. The sodium salt (Sodium salicylate), a shiny white powder, is used for antiseptics preparations and as a preservative. In addition to its analgesic and antipyretic properties, salicylic acid possesses keratinolytic properties and fungicidal properties. It ans its derivatives are used in the treatment of hyperkeratotic, dandruff, ichthyosis and psoriasis as well as in the treatment of fungal skin infections such as tinea. Para-Aminosalicylic acid (abbreviated PAS and PASA) is an analogue of para-aminobenzoic acid (abbreviated PABA) that inhibits folic acid synthesis in Mycobacterium tuberculosis and is bacteriostatic, inhibits growth and multiplication of the tubercle bacillus. Para-Aminosalicylic acid and its sodium salt (sodium p-Aminosalicylate) are bacteriostatic against mycobacteria and used in the treatment of tuberculosis; administered orally. Brand names are Tubasal, Nemasol Sodium and etc. Aminosalicylic acids are pharmaceutically active ingredients including anti-infectives against colds, flu, or other virus infections. Mesalamine (5-aminosalicylic acid, abbreviated 5-ASA) an active metabolite of sulfasalazine, used to treat inflammation of the rectum and lower colon, mild to moderate ulcerative colitis proctosigmoiditis, and proctitis. Para-Aminosalicylic acid (4-hydroxybenzoic acid) is used as an intermediate of bacteriostatic agent specially for parabens (alkyl esters of p-hydroxy benzoic acid) which used in food and personal care products as a preservative. It is applied in the production of liquid crystal polymers. It is also used as an intermediate of dyes, insecticides, pharmaceutical, pesticides and other chemical compounds. Salicylic Acid and its derivatives are important for the preparation of other pharmaceutical products, dyes, flavours, and preservatives.
SALES SPECIFICATION

APPEARANCE

 white crystalline powder
ASSAY 99.0% min

MELTING POINT

171 - 173 C

WATER

0.5% max

RESIDUE ON IGNITION

0.5% max
TRANSPORTATION
PACKING 25kgs in bag
HAZARD CLASS Not regulated
UN NO.  
OTHER INFORMATION

Hazard Symbols: XN, Risk Phrases: 22-36/38, Safety Phrases: 26-36